User:Mandy Bechman/Sandbox 1: Difference between revisions
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Glucose-dependent insulinotropic polypeptide (GIP) is a gastric inhibitory polypeptide. It is categorized as a incretin, which is a gut-based hormone that is secreted upon the ingestion of food. It is found in K cells in the upper small intestines of humans. | Glucose-dependent insulinotropic polypeptide (GIP) is a gastric inhibitory polypeptide. It is categorized as a incretin, which is a gut-based hormone that is secreted upon the ingestion of food. It is found in K cells in the upper small intestines of humans. | ||
===History=== | ===History=== | ||
The idea of incretin began in 1902 after the discovery of secretin | The idea of incretin began in 1902 after the discovery of secretin by Bayliss and Starling. Inspired by their discovery, Moore et al. hypothesized that there must be some kind of gut hormone that regulates the endocrine pancreas. His experiments showed that gut extracts in patients with diabetes have reduced amounts of sugars in their urine as a result of endocrine stimulation. In 1929, a French scientist named La Barre was able to purify incretin from gut extracts. The name incretin comes from INtestine seCRETion INsulin. | ||
==Structure Overview== | ==Structure Overview== | ||
GIP is a G-coupled receptor. It is composed of the alpha, beta, and gamma subunits. | GIP is a G-coupled receptor. It is composed of the alpha, beta, and gamma subunits. | ||
Revision as of 14:31, 28 March 2024
H. sapiens Glucose-dependent Insulinotropic Polypeptide
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References
- ↑ Seino Y, Fukushima M, Yabe D. GIP and GLP-1, the two incretin hormones: Similarities and differences. J Diabetes Investig. 2010 Apr 22;1(1-2):8-23. PMID:24843404 doi:10.1111/j.2040-1124.2010.00022.x
- ↑ Mayendraraj A, Rosenkilde MM, Gasbjerg LS. GLP-1 and GIP receptor signaling in beta cells interactions and co-stimulation. Peptides. 2022 May;151:170749. PMID:35065096 doi:10.1016/j.peptides.2022.170749
