1rer: Difference between revisions

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[[Image:1rer.gif|left|200px]]
{{Seed}}
[[Image:1rer.png|left|200px]]


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{{STRUCTURE_1rer|  PDB=1rer  |  SCENE=  }}  
{{STRUCTURE_1rer|  PDB=1rer  |  SCENE=  }}  


'''Crystal structure of the homotrimer of fusion glycoprotein E1 from Semliki Forest Virus.'''
===Crystal structure of the homotrimer of fusion glycoprotein E1 from Semliki Forest Virus.===




==Overview==
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Fusion of biological membranes is mediated by specific lipid-interacting proteins that induce the formation and expansion of an initial fusion pore. Here we report the crystal structure of the ectodomain of the Semliki Forest virus fusion glycoprotein E1 in its low-pH-induced trimeric form. E1 adopts a folded-back conformation that, in the final post-fusion form of the full-length protein, would bring the fusion peptide loop and the transmembrane anchor to the same end of a stable protein rod. The observed conformation of the fusion peptide loop is compatible with interactions only with the outer leaflet of the lipid bilayer. Crystal contacts between fusion peptide loops of adjacent E1 trimers, together with electron microscopy observations, suggest that in an early step of membrane fusion, an intermediate assembly of five trimers creates two opposing nipple-like deformations in the viral and target membranes, leading to formation of the fusion pore.
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{{ABSTRACT_PUBMED_14737160}}


==About this Structure==
==About this Structure==
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[[Category: Membrane fusion]]
[[Category: Membrane fusion]]
[[Category: Virus.]]
[[Category: Virus.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:24:17 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:59:08 2008''

Revision as of 20:59, 27 July 2008

File:1rer.png

Template:STRUCTURE 1rer

Crystal structure of the homotrimer of fusion glycoprotein E1 from Semliki Forest Virus.

Template:ABSTRACT PUBMED 14737160

About this Structure

1RER is a Single protein structure of sequence from Semliki forest virus. Full crystallographic information is available from OCA.

Reference

Conformational change and protein-protein interactions of the fusion protein of Semliki Forest virus., Gibbons DL, Vaney MC, Roussel A, Vigouroux A, Reilly B, Lepault J, Kielian M, Rey FA, Nature. 2004 Jan 22;427(6972):320-5. PMID:14737160

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