8yn2: Difference between revisions
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==Cryo-EM structure of histamine H1 receptor in complex with histamine and miniGq== | |||
<StructureSection load='8yn2' size='340' side='right'caption='[[8yn2]], [[Resolution|resolution]] 2.66Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8yn2]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YN2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.66Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=HSM:HISTAMINE'>HSM</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yn2 OCA], [https://pdbe.org/8yn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yn2 RCSB], [https://www.ebi.ac.uk/pdbsum/8yn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yn2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Gong W]] | |||
[[Category: Li X]] | |||
[[Category: Liu G]] | |||
[[Category: Zhang X]] | |||
Latest revision as of 07:05, 9 October 2024
Cryo-EM structure of histamine H1 receptor in complex with histamine and miniGq
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