1rfa: Difference between revisions

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[[Image:1rfa.gif|left|200px]]
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[[Image:1rfa.png|left|200px]]


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{{STRUCTURE_1rfa|  PDB=1rfa  |  SCENE=  }}  
{{STRUCTURE_1rfa|  PDB=1rfa  |  SCENE=  }}  


'''NMR SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF C-RAF-1'''
===NMR SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF C-RAF-1===




==Overview==
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The structure of the Ras-binding domain of human c-Raf-1 (residues 55-132) has been determined in solution by nuclear magnetic resonance (NMR) spectroscopy. Following complete assignment of the backbone and side-chain 1H, 15N, and 13C resonances, the structure was calculated using the program CHARMM. Over 1300 NOE-derived constraints were applied, resulting in a detailed structure. The fold of Raf55-132 consists of a five-stranded beta-sheet, a 12-residue alpha-helix, and an additional one-turn helix. It is similar to those of ubiquitin and the IgG-binding domain of protein G, although the three proteins share very little sequence identity. The surface of Raf55-132 that interacts with Ras has been identified by monitoring perturbation of line widths and chemical shifts of 15N-labeled Raf55-132 resonances during titration with unlabeled Ras-GMPPNP. The Ras-binding site is contained within a spatially contiguous patch comprised of the N-terminal beta-hairpin and the C-terminal end of the alpha-helix.
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{{ABSTRACT_PUBMED_7766599}}


==About this Structure==
==About this Structure==
1RFA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RFA OCA].  
1RFA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RFA OCA].  


==Reference==
==Reference==
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[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Signal transduction protein]]
[[Category: Signal transduction protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:25:32 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:04:53 2008''

Revision as of 14:04, 28 July 2008

File:1rfa.png

Template:STRUCTURE 1rfa

NMR SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF C-RAF-1

Template:ABSTRACT PUBMED 7766599

About this Structure

1RFA is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the Ras-binding domain of c-Raf-1 and identification of its Ras interaction surface., Emerson SD, Madison VS, Palermo RE, Waugh DS, Scheffler JE, Tsao KL, Kiefer SE, Liu SP, Fry DC, Biochemistry. 1995 May 30;34(21):6911-8. PMID:7766599

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