1ri9: Difference between revisions

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[[Image:1ri9.gif|left|200px]]
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[[Image:1ri9.png|left|200px]]


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{{STRUCTURE_1ri9|  PDB=1ri9  |  SCENE=  }}  
{{STRUCTURE_1ri9|  PDB=1ri9  |  SCENE=  }}  


'''Structure of a helically extended SH3 domain of the T cell adapter protein ADAP'''
===Structure of a helically extended SH3 domain of the T cell adapter protein ADAP===




==Overview==
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The adapter protein ADAP (FYB/SLAP-130) provides a critical link between T cell receptor (TCR) signaling and cell adhesion via the activation of integrins. The C-terminal 70 residues of ADAP show homology to SH3 domains; however, conserved residues of the fold are absent. An alignment and annotation of this domain has therefore been elusive. We have solved the three-dimensional structure of the ADAP C-terminal domain by NMR spectroscopy and show that it represents an altered SH3 domain fold. An N-terminal, amphipathic helix makes extensive contacts to residues of the regular SH3 domain fold, and thereby a composite surface with unusual surface properties is created. We propose this SH3 domain variant to be classified as a helically extended SH3 domain (hSH3 domain) and show that the ADAP-hSH3 domain can no longer bind conventional proline-rich peptides.
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{{ABSTRACT_PUBMED_15062083}}


==About this Structure==
==About this Structure==
1RI9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RI9 OCA].  
1RI9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RI9 OCA].  


==Reference==
==Reference==
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[[Category: Helically extended]]
[[Category: Helically extended]]
[[Category: Sh3-like]]
[[Category: Sh3-like]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:14:57 2008''

Revision as of 03:15, 29 July 2008

File:1ri9.png

Template:STRUCTURE 1ri9

Structure of a helically extended SH3 domain of the T cell adapter protein ADAP

Template:ABSTRACT PUBMED 15062083

About this Structure

1RI9 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of a helically extended SH3 domain of the T cell adapter protein ADAP., Heuer K, Kofler M, Langdon G, Thiemke K, Freund C, Structure. 2004 Apr;12(4):603-10. PMID:15062083

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