1u35: Difference between revisions

Line 1:

[[Image:1u35.gif|left|200px]]<br />

[[Image:1u35.gif|left|200px]]<br /><applet load="1u35" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1u35" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1u35, resolution 3.0Å" />

'''Crystal structure of the nucleosome core particle containing the histone domain of macroH2A'''<br />

==Overview==

macroH2A is an H2A variant with a highly unusual structural organization., It has a C-terminal domain connected to the N-terminal histone domain by a, linker. Crystallographic and biochemical studies show that changes in the, L1 loop in the histone fold region of macroH2A impact the structure and, potentially the function of nucleosomes. The 1.6-A X-ray structure of the, nonhistone region reveals an alpha/beta fold which has previously been, found in a functionally diverse group of proteins. This region associates, with histone deacetylases and affects the acetylation status of, nucleosomes containing macroH2A. Thus, the unusual domain structure of, macroH2A integrates independent functions that are instrumental in, establishing a structurally and functionally unique chromatin domain.

macroH2A is an H2A variant with a highly unusual structural organization. It has a C-terminal domain connected to the N-terminal histone domain by a linker. Crystallographic and biochemical studies show that changes in the L1 loop in the histone fold region of macroH2A impact the structure and potentially the function of nucleosomes. The 1.6-A X-ray structure of the nonhistone region reveals an alpha/beta fold which has previously been found in a functionally diverse group of proteins. This region associates with histone deacetylases and affects the acetylation status of nucleosomes containing macroH2A. Thus, the unusual domain structure of macroH2A integrates independent functions that are instrumental in establishing a structurally and functionally unique chromatin domain.

==About this Structure==

1U35 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1U35 OCA].

1U35 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U35 OCA].

==Reference==

Line 17:

Line 16:

[[Category: Caron, C.]]

[[Category: Chakravarthy, S.]]

[[Category: Gundimella, S.K.]]

[[Category: Gundimella, S K.]]

[[Category: Khochbin, S.]]

[[Category: Luger, K.]]

[[Category: Pehrson, J.R.]]

[[Category: Pehrson, J R.]]

[[Category: Perche, P.Y.]]

[[Category: Perche, P Y.]]

[[Category: histone fold]]

[[Category: histone variant]]

Line 28:

Line 27:

[[Category: nucleosome]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 19~~:30:~~53 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:20:09 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1u35.gif|left|200px]]<br />
+[[Image:1u35.gif|left|200px]]<br /><applet load="1u35" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1u35" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1u35, resolution 3.0&Aring;" />
 '''Crystal structure of the nucleosome core particle containing the histone domain of macroH2A'''<br />
 ==Overview==
-macroH2A is an H2A variant with a highly unusual structural organization., It has a C-terminal domain connected to the N-terminal histone domain by a, linker. Crystallographic and biochemical studies show that changes in the, L1 loop in the histone fold region of macroH2A impact the structure and, potentially the function of nucleosomes. The 1.6-A X-ray structure of the, nonhistone region reveals an alpha/beta fold which has previously been, found in a functionally diverse group of proteins. This region associates, with histone deacetylases and affects the acetylation status of, nucleosomes containing macroH2A. Thus, the unusual domain structure of, macroH2A integrates independent functions that are instrumental in, establishing a structurally and functionally unique chromatin domain.
+macroH2A is an H2A variant with a highly unusual structural organization. It has a C-terminal domain connected to the N-terminal histone domain by a linker. Crystallographic and biochemical studies show that changes in the L1 loop in the histone fold region of macroH2A impact the structure and potentially the function of nucleosomes. The 1.6-A X-ray structure of the nonhistone region reveals an alpha/beta fold which has previously been found in a functionally diverse group of proteins. This region associates with histone deacetylases and affects the acetylation status of nucleosomes containing macroH2A. Thus, the unusual domain structure of macroH2A integrates independent functions that are instrumental in establishing a structurally and functionally unique chromatin domain.
 ==About this Structure==
-U35 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1U35 OCA].
+U35 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U35 OCA].
 ==Reference==
@@ Line 17: / Line 16: @@
 [[Category: Caron, C.]]
 [[Category: Chakravarthy, S.]]
-[[Category: Gundimella, S.K.]]
+[[Category: Gundimella, S K.]]
 [[Category: Khochbin, S.]]
 [[Category: Luger, K.]]
-[[Category: Pehrson, J.R.]]
+[[Category: Pehrson, J R.]]
-[[Category: Perche, P.Y.]]
+[[Category: Perche, P Y.]]
 [[Category: histone fold]]
 [[Category: histone variant]]
@@ Line 28: / Line 27: @@
 [[Category: nucleosome]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:30:53 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:20:09 2008''