1rm0: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:1rm0.gif|left|200px]]
{{Seed}}
[[Image:1rm0.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1rm0|  PDB=1rm0  |  SCENE=  }}  
{{STRUCTURE_1rm0|  PDB=1rm0  |  SCENE=  }}  


'''Crystal Structure of Myo-Inositol 1-Phosphate Synthase From Saccharomyces cerevisiae In Complex With NAD+ and 2-deoxy-D-glucitol 6-(E)-vinylhomophosphonate'''
===Crystal Structure of Myo-Inositol 1-Phosphate Synthase From Saccharomyces cerevisiae In Complex With NAD+ and 2-deoxy-D-glucitol 6-(E)-vinylhomophosphonate===




==Overview==
<!--  
1l-myo-inositol 1-phosphate (MIP) synthase catalyzes the conversion of d-glucose 6-phosphate to 1l-myo-inositol 1-phosphate, the first and rate-limiting step in the biosynthesis of all inositol-containing compounds. It involves an oxidation, enolization, intramolecular aldol cyclization, and reduction. Here we present the structure of MIP synthase in complex with NAD(+) and a high-affinity inhibitor, 2-deoxy-d-glucitol 6-(E)-vinylhomophosphonate. This structure reveals interactions between the enzyme active site residues and the inhibitor that are significantly different from that proposed for 2-deoxy-d-glucitol 6-phosphate in the previously published structure of MIP synthase-NAD(+)-2-deoxy-d-glucitol 6-phosphate. There are several other conformational changes in NAD(+) and the enzyme active site as well. Based on the new structural data, we propose a new and completely different mechanism for MIP synthase.
The line below this paragraph, {{ABSTRACT_PUBMED_14684747}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 14684747 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_14684747}}


==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Jin, X.]]
[[Category: Jin, X.]]
[[Category: Myo-inositol 1-phosphate synthase]]
[[Category: Myo-inositol 1-phosphate synthase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:39:34 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:27:03 2008''
Retrieved from "https://proteopedia.org/1rm0"