1rn7: Difference between revisions

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[[Image:1rn7.gif|left|200px]]
{{Seed}}
[[Image:1rn7.png|left|200px]]


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{{STRUCTURE_1rn7|  PDB=1rn7  |  SCENE=  }}  
{{STRUCTURE_1rn7|  PDB=1rn7  |  SCENE=  }}  


'''Structure of human cystatin D'''
===Structure of human cystatin D===




==Overview==
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Cystatins are natural inhibitors of papain-like (family C1) and legumain-related (family C13) cysteine peptidases. Cystatin D is a type 2 cystatin, a secreted inhibitor found in human saliva and tear fluid. Compared with its homologues, cystatin D presents an unusual inhibition profile with a preferential inhibition cathepsin S &gt; cathepsin H &gt; cathepsin L and no inhibition of cathepsin B or pig legumain. To elucidate the structural reasons for this specificity, we have crystallized recombinant human Arg(26)-cystatin D and solved its structures at room temperature and at cryo conditions to 2.5- and 1.8-A resolution, respectively. Human cystatin D presents the typical cystatin fold, with a five-stranded anti-parallel beta-sheet wrapped around a five-turn alpha-helix. The structures reveal differences in the peptidase-interacting regions when compared with other cystatins, providing plausible explanations for the restricted inhibitory specificity of cystatin D for some papain-like peptidases and its lack of reactivity toward legumain-related enzymes.
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{{ABSTRACT_PUBMED_15728581}}


==About this Structure==
==About this Structure==
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[[Category: Cystatin d]]
[[Category: Cystatin d]]
[[Category: Inhibitor of cysteine peptidase]]
[[Category: Inhibitor of cysteine peptidase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:41:29 2008''
 
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Revision as of 15:39, 27 July 2008

File:1rn7.png

Template:STRUCTURE 1rn7

Structure of human cystatin D

Template:ABSTRACT PUBMED 15728581

About this Structure

1RN7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile., Alvarez-Fernandez M, Liang YH, Abrahamson M, Su XD, J Biol Chem. 2005 May 6;280(18):18221-8. Epub 2005 Feb 23. PMID:15728581

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