1u6q: Difference between revisions
New page: left|200px<br /> <applet load="1u6q" size="450" color="white" frame="true" align="right" spinBox="true" caption="1u6q, resolution 2.02Å" /> '''Substituted 2-Napht... |
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[[Image:1u6q. | [[Image:1u6q.jpg|left|200px]]<br /><applet load="1u6q" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="1u6q, resolution 2.02Å" /> | caption="1u6q, resolution 2.02Å" /> | ||
'''Substituted 2-Naphthamadine inhibitors of Urokinase'''<br /> | '''Substituted 2-Naphthamadine inhibitors of Urokinase'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1U6Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 745 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] Full crystallographic information is available from [http:// | 1U6Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=745:'>745</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6Q OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:59:23 2008'' | ||
Revision as of 14:59, 15 February 2008
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Substituted 2-Naphthamadine inhibitors of Urokinase
Overview
A series of non-amide-linked 6-substituted-2-naphthamidine urokinase, plasminogen activator (uPA) inhibitors are described. These compounds, possess excellent binding activities and selectivities with significantly, improved pharmacokinetic profiles versus previously described amide-linked, inhibitors.
Disease
Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[191840]
About this Structure
1U6Q is a Single protein structure of sequence from Homo sapiens with 745 as ligand. Active as U-plasminogen activator, with EC number 3.4.21.73 Full crystallographic information is available from OCA.
Reference
Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties., Bruncko M, McClellan WJ, Wendt MD, Sauer DR, Geyer A, Dalton CR, Kaminski MA, Weitzberg M, Gong J, Dellaria JF, Mantei R, Zhao X, Nienaber VL, Stewart K, Klinghofer V, Bouska J, Rockway TW, Giranda VL, Bioorg Med Chem Lett. 2005 Jan 3;15(1):93-8. PMID:15582418
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