1rod: Difference between revisions

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[[Image:1rod.gif|left|200px]]
{{Seed}}
[[Image:1rod.png|left|200px]]


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{{STRUCTURE_1rod|  PDB=1rod  |  SCENE=  }}  
{{STRUCTURE_1rod|  PDB=1rod  |  SCENE=  }}  


'''CHIMERIC PROTEIN OF INTERLEUKIN 8 AND HUMAN MELANOMA GROWTH STIMULATING ACTIVITY PROTEIN, NMR'''
===CHIMERIC PROTEIN OF INTERLEUKIN 8 AND HUMAN MELANOMA GROWTH STIMULATING ACTIVITY PROTEIN, NMR===




==Overview==
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A 72-amino-acid chimeric protein, Chi1, was constructed from the N-terminal part of interleukin 8, IL-8-(1-53), and the C-terminal part of melanoma growth stimulatory activity, MGSA-(54-72). Chi1 protein showed receptor-binding specificity and biological activity similar, but not identical to IL-8 and decidedly different from MGSA. The structure of Chi1 was determined in solution by two-dimensional NMR and molecular-dynamics calculations. The structure resembled the structures of MGSA and IL-8 closely, containing a triple-stranded beta-sheet in the IL-8 part and an amphipathic alpha-helix in the MGSA part. Chi1 formed dimers at millimolar concentrations via the first strand from the N-terminus, analogous to IL-8 and MGSA. In contrast to the latter molecules, however, the alpha-helix of Chi1 did not pack against the beta-sheet part, but was an independent structural element. This structural difference could be explained mainly by the modulation of hydrophobic interactions between the helix and the rest of the protein in Chi1 as compared to IL-8 and MGSA. It is concluded that tight helix packing is not required for receptor binding and biological activity of Chi1.
The line below this paragraph, {{ABSTRACT_PUBMED_8631339}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8631339 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8631339}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ROD OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ROD OCA].  


==Reference==
==Reference==
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[[Category: Cytokine]]
[[Category: Cytokine]]
[[Category: Inflammatory response]]
[[Category: Inflammatory response]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:43:37 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:44:46 2008''

Revision as of 00:44, 29 July 2008

File:1rod.png

Template:STRUCTURE 1rod

CHIMERIC PROTEIN OF INTERLEUKIN 8 AND HUMAN MELANOMA GROWTH STIMULATING ACTIVITY PROTEIN, NMR

Template:ABSTRACT PUBMED 8631339

About this Structure

Full experimental information is available from OCA.

Reference

Structure and activity of a chimeric interleukin-8-melanoma-growth-stimulatory-activity protein., Sticht H, Auer M, Schmitt B, Besemer J, Horcher M, Kirsch T, Lindley IJ, Rosch P, Eur J Biochem. 1996 Jan 15;235(1-2):26-35. PMID:8631339

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