User:Mandy Bechman/Sandbox 1: Difference between revisions
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== Function == | == Function == | ||
[[Image:GIPmech.jpg|350 px|left|thumb|Mechanism]] | [[Image:GIPmech.jpg|350 px|left|thumb|Mechanism of GIP activation and deactivation.]] | ||
The mechanism of GIP begins with the ingestion of food. This stimulates GIP to bind to its receptor. Once bound, the activated G alpha protein moves laterally in the membrane in order to activate its target, adenylyl cyclase. Once adenylyl cyclase is activated, it catalyzes the formation of cyclic AMP (cAMP). This molecule activates Protein Kinase A (PKA), which signals the secretin of insulin. After a few minutes of active signaling, this | The mechanism of GIP begins with the ingestion of food. This stimulates GIP to bind to its receptor. Once bound, the activated G alpha protein moves laterally in the membrane in order to activate its target, adenylyl cyclase. Once adenylyl cyclase is activated, it catalyzes the formation of cyclic AMP (cAMP). This molecule activates Protein Kinase A (PKA), which signals the secretin of insulin. After a few minutes of active signaling, this hormone is recognized and inactivated by a peptidase called DPP-4 (dipeptidyl peptidase-4) by cleaving the first two amino acids. | ||
