Sandbox Ben Whiteside: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 22: | Line 22: | ||
=== Two-Domain Model of Amylin Binding === | === Two-Domain Model of Amylin Binding === | ||
It is hypothesized that amylin binds to the receptor via a two-domain model. The model suggests a series of steps for how amylin binds. First, the c-terminus of amylin binds to the n terminus of the extracellular domain of the receptor. This binding factors the alignment of amylin's n-terminus to the primary GPCR binding site. This activates the GPCR, leading to subsequent activation of adenylyl cyclase and cAMP release. [[Image:Domain_drawingnew.jpg|300px|left|thumb|Two Domain Model ]] | It is hypothesized that amylin binds to the receptor via a two-domain model. The model suggests a series of steps for how amylin binds. First, the c-terminus of amylin binds to the n terminus of the extracellular domain of the receptor. This binding factors the alignment of amylin's n-terminus to the primary GPCR binding site. This activates the GPCR, leading to subsequent activation of adenylyl cyclase and cAMP release. [[Image:Domain_drawingnew.jpg|300px|left|thumb|Two Domain Model ]] | ||
===RAMP-CTR Interface | ===RAMP-CTR Interface=== | ||
<scene name='10/1038828/Ramp_ctr_interface/9'>RAMP CTR Interface </scene> is a key interaction that stabilizes the protein complex and positions the receptor to favorably bind to amylin. The RAMP-CTR interface extends into the plasma membrane, providing additional non-covalent bonding between the protein complex and the cell membrane. | <scene name='10/1038828/Ramp_ctr_interface/9'>RAMP CTR Interface </scene> is a key interaction that stabilizes the protein complex and positions the receptor to favorably bind to amylin. The RAMP-CTR interface extends into the plasma membrane, providing additional non-covalent bonding between the protein complex and the cell membrane. | ||
==== Extracellular Domain - RAMP interactions ==== | ==== Extracellular Domain - RAMP interactions ==== | ||
