User:Brynn Baker/Sandbox1: Difference between revisions
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== RAMPs == | == RAMPs == | ||
To form the full AMYR complex, the calcitonin receptor must bind to one of three RAMPs (insert RAMP images). The three RAMPs have 31% sequence identity and bind very similarly to the CT, except RAMP2 has slightly looser packing<ref name="Cao">PMID:35324283</ref>. All three RAMPs serve the purpose of drastically increasing the CT’s binding affinity for amylin. RAMP3 is the version most heavily implicated in pramlintide targeting and Alzheimer’s Disease. | To form the full AMYR complex, the calcitonin receptor must bind to one of three RAMPs (insert RAMP images). The three RAMPs have 31% sequence identity and bind very similarly to the CT, except RAMP2 has slightly looser packing<ref name="Cao">PMID:35324283</ref>. All three RAMPs serve the purpose of drastically increasing the CT’s binding affinity for amylin. RAMP3 is the version most heavily implicated in pramlintide targeting and Alzheimer’s Disease. | ||
[[Image: | [[Image:Rampstestmm2.jpg|300 px|right|thumb|Figure 4. Superimposed RAMP1 (pink), RAMP2 (blue), and RAMP3 (tan) in the human amylin receptor (CT is gray).]] | ||
=== Amylin Binding === | === Amylin Binding === | ||
