User:Brynn Baker/Sandbox1: Difference between revisions
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=== Amylin Binding === | === Amylin Binding === | ||
Y37 of amylin, the C-terminal residue, forms hydrogen bonds with E101 in RAMP2 or E74 in RAMP3. It also forms van der Waals interactions with F111 in RAMP2 or W84 and P85 in both RAMP1 and | Y37 of amylin, the C-terminal residue, forms hydrogen bonds with E101 in RAMP2 or E74 in RAMP3. It also forms van der Waals interactions with F111 in RAMP2 or W84 and P85 in both <scene name='10/1037520/Y37_and_ramp1/1'>RAMP1</scene> and RAMP3. Uniquely, in RAMP3, W84 can adopt two conformations in RAMP3; one of which lies closer to Y37 and the other aligns almost perfectly with W84’s placement in RAMP1<ref name="Cao">PMID:35324283</ref>. | ||
== Amylin Receptor Functional Overview == | == Amylin Receptor Functional Overview == | ||
