User:Mandy Bechman/Sandbox 1: Difference between revisions
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==Structure Overview== | ==Structure Overview== | ||
===G-proteins=== | ===G-proteins=== | ||
GIP is a G-coupled receptor. It is a 7 helical transmembrane domain with the ligand in dark blue and the helices in light blue. It contains alpha, beta, and gamma <scene name='10/1038867/Structure_overview/11'>subunits</scene> located in the intracellular domain. The G alpha subunit makes interactions with the beta and gamma subunits that when bound to ATP, activates the G alpha protein and is released by the other subunits to bind to target, i.e. adenylyl cycle in order to activate the process of insulin secretion. | GIP is a G-coupled receptor [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020673/ GPCR]. It is a 7 helical transmembrane domain with the ligand in dark blue and the helices in light blue. It contains alpha, beta, and gamma <scene name='10/1038867/Structure_overview/11'>subunits</scene> located in the intracellular domain. The G alpha subunit makes interactions with the beta and gamma subunits that when bound to ATP, activates the G alpha protein and is released by the other subunits to bind to target, i.e. adenylyl cycle in order to activate the process of insulin secretion. | ||
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===Diseases=== | ===Diseases=== | ||
Malfunction of the GIP protein can result in some | Malfunction of the GIP protein can result in some serious life-threatening diseases. Overexpression of GIP can result in obesity by promoting fat disposition in adipocyte tissues as well as an inability to regulate food intake and control appetite. Underexpression of GIP can result in diabetes. | ||
