User:Brynn Baker/Sandbox1: Difference between revisions
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== Introduction == | == Introduction == | ||
In 1900, amylin deposits were first discovered in [https://en.wikipedia.org/wiki/Pancreatic_islets pancreatic islet cells] in diabetic patients. Later in 1943, it was determined that these amylin deposits were [https://en.wikipedia.org/wiki/Amyloid amyloid] in nature. By the 1980s, the 37 amino acid sequence of amylin was identified. By 1995, the first analogue of amylin, [https://en.wikipedia.org/wiki/Pramlintide pramlintide], was synthesized. In the late 1990s, it was discovered, through [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryogenic electron microscopy], that the amylin receptor was made of the [https://en.wikipedia.org/wiki/Calcitonin_receptor calcitonin receptor (CT)] core, which heterodimerizes with a [https://en.wikipedia.org/wiki/Receptor_activity-modifying_protein receptor-activating modifying protein (RAMP)] to form different amylin receptors. The human amylin receptor is also a [https://en.wikipedia.org/wiki/G_protein-coupled_receptor G-coupled | In 1900, amylin deposits were first discovered in [https://en.wikipedia.org/wiki/Pancreatic_islets pancreatic islet cells] in diabetic patients. Later in 1943, it was determined that these amylin deposits were [https://en.wikipedia.org/wiki/Amyloid amyloid] in nature. By the 1980s, the 37 amino acid sequence of amylin was identified. By 1995, the first analogue of amylin, [https://en.wikipedia.org/wiki/Pramlintide pramlintide], was synthesized. In the late 1990s, it was discovered, through [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryogenic electron microscopy], that the amylin receptor was made of the [https://en.wikipedia.org/wiki/Calcitonin_receptor calcitonin receptor (CT)] core, which heterodimerizes with a [https://en.wikipedia.org/wiki/Receptor_activity-modifying_protein receptor-activating modifying protein (RAMP)] to form different amylin receptors. The human amylin receptor is also a [https://en.wikipedia.org/wiki/G_protein-coupled_receptor G-protein coupled receptor]. | ||
== Amylin == | == Amylin == | ||
