Sandbox Ben Whiteside: Difference between revisions
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=== Bypass Motif === | === Bypass Motif === | ||
=== G-alpha Interactions with CTR TMD === | === G-alpha Interactions with CTR TMD === | ||
To transduce the signal across the cell membrane, the binding of amylin will induce a conformational change that allows for the CTR to make favorable interactions with the G alpha subunit. Two interactions shown <scene name='10/1038828/Ctr_g_alpha/15'>(1, </scene><scene name='10/1038828/Ctr_g_alpha/12'>2) </scene> activate the G-protein and propel downstream signaling. | To transduce the signal across the cell membrane, the binding of amylin will induce a conformational change that allows for the CTR to make favorable interactions with the G alpha subunit. Two interactions shown <scene name='10/1038828/Ctr_g_alpha/15'>(1, </scene><scene name='10/1038828/Ctr_g_alpha/12'>2) </scene> activate the G-protein and propel downstream signaling. As with a typical glucagon GPCR pathway, the activated G-alpha subunit becomes activated upon guanine exchange factor [https://en.wikipedia.org/wiki/Guanine_nucleotide_exchange_factor GEF] activity. This G-alpha subunit transverses laterally in the membrane towards adenylyl cyclase, activating it and causing an increase in the second messenger cyclic adenosine monophosphate [https://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphate cAMP]. This cAMP activates protein kinase A [https://en.wikipedia.org/wiki/Protein_kinase_A PKA], which can phosphorylate other proteins facilitating cellular response. | ||
