1u9w: Difference between revisions
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New page: left|200px<br /> <applet load="1u9w" size="450" color="white" frame="true" align="right" spinBox="true" caption="1u9w, resolution 2.3Å" /> '''Crystal Structure of... |
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[[Image:1u9w.gif|left|200px]]<br /> | [[Image:1u9w.gif|left|200px]]<br /><applet load="1u9w" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1u9w" size=" | |||
caption="1u9w, resolution 2.3Å" /> | caption="1u9w, resolution 2.3Å" /> | ||
'''Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABI491'''<br /> | '''Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABI491'''<br /> | ||
==Overview== | ==Overview== | ||
Starting from the high-throughput screening hit 1a, novel cathepsin K | Starting from the high-throughput screening hit 1a, novel cathepsin K inhibitors have been developed based on a purine scaffold. High-resolution X-ray structures of several derivatives have revealed the binding mode of these unique cysteine protease inhibitors. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1U9W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with IHI as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] Full crystallographic information is available from [http:// | 1U9W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=IHI:'>IHI</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9W OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Cowan-Jacob, S | [[Category: Cowan-Jacob, S W.]] | ||
[[Category: IHI]] | [[Category: IHI]] | ||
[[Category: hydrolase]] | [[Category: hydrolase]] | ||
[[Category: sulfhydryl proteinase]] | [[Category: sulfhydryl proteinase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:22:12 2008'' | ||
