Sandbox324: Difference between revisions
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The role in the body this would play based on results. Any potential implications of the enzyme if disrupted based on findings and related enzymes. | The role in the body this would play based on results. Any potential implications of the enzyme if disrupted based on findings and related enzymes. | ||
This protein belongs to the esterase family and expresses alpha/beta-hydrolase activity. Esterases are broadly defined as hydrolases that split ester, amide, and/or thioester bonds in certain compounds that cause prodrug activation and/or detoxification.<ref>Fukami, T.; Yokoi, T. The Emerging Role of Human Esterases. Drug Metabolism and Pharmacokinetics 2012, 27 (5), 466–477. https://doi.org/10.2133/dmpk.dmpk-12-rv-042.</ref> | This protein belongs to the esterase family and expresses alpha/beta-hydrolase activity. Esterases are broadly defined as hydrolases that split ester, amide, and/or thioester bonds in certain compounds that cause prodrug activation and/or detoxification. The ability of esterases to hydrolyze various drugs make them an important component in drug metabolism<ref>Fukami, T.; Yokoi, T. The Emerging Role of Human Esterases. Drug Metabolism and Pharmacokinetics 2012, 27 (5), 466–477. https://doi.org/10.2133/dmpk.dmpk-12-rv-042.</ref>. This protein's close association with carboxylesterases also indicates that this protein is potentially involved in the hydrolysis of carboxylic ester bonds. Drug metabolism (drug hydrolysis, drug absorption<ref>Williams, F. M. Clinical Significance of Esterases in Man. Clinical pharmacokinetics 1985, 10 (5), 392–403. https://doi.org/10.2165/00003088-198510050-00002.</ref>, etc.) would be inhibited if the function of an esterase is disrupted. | ||
== Proposed Function == | == Proposed Function == | ||
