1rti: Difference between revisions

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[[Image:1rti.jpg|left|200px]]
{{Seed}}
[[Image:1rti.png|left|200px]]


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{{STRUCTURE_1rti|  PDB=1rti  |  SCENE=  }}  
{{STRUCTURE_1rti|  PDB=1rti  |  SCENE=  }}  


'''HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES'''
===HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES===




==Overview==
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We have determined the structures of four complexes of HIV-1 reverse transcriptase with non-nucleoside inhibitors, three fully refined at high resolution. The highest resolution structure is of the RT-nevirapine complex which has an R-factor of 0.186 and a root-mean-square bond length deviation of 0.015 A for all data to 2.2 A. The structures reveal a common mode of binding for these chemically diverse compounds. The common features of binding are largely hydrophobic interactions and arise from induced shape complementarity achieved by conformational rearrangement of the enzyme and conformational/configurational rearrangement of the compounds.
The line below this paragraph, {{ABSTRACT_PUBMED_7540934}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_7540934}}


==About this Structure==
==About this Structure==
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[[Category: Stuart, D.]]
[[Category: Stuart, D.]]
[[Category: Hiv-1 reverse transcriptase]]
[[Category: Hiv-1 reverse transcriptase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:53:17 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:33:51 2008''

Revision as of 16:33, 28 July 2008

File:1rti.png

Template:STRUCTURE 1rti

HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES

Template:ABSTRACT PUBMED 7540934

About this Structure

1RTI is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

High resolution structures of HIV-1 RT from four RT-inhibitor complexes., Ren J, Esnouf R, Garman E, Somers D, Ross C, Kirby I, Keeling J, Darby G, Jones Y, Stuart D, et al., Nat Struct Biol. 1995 Apr;2(4):293-302. PMID:7540934

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