1rvx: Difference between revisions

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[[Image:1rvx.gif|left|200px]]
{{Seed}}
[[Image:1rvx.png|left|200px]]


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{{STRUCTURE_1rvx|  PDB=1rvx  |  SCENE=  }}  
{{STRUCTURE_1rvx|  PDB=1rvx  |  SCENE=  }}  


'''1934 H1 Hemagglutinin in complex with LSTA'''
===1934 H1 Hemagglutinin in complex with LSTA===




==Overview==
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The 1918 influenza pandemic resulted in about 20 million deaths. This enormous impact, coupled with renewed interest in emerging infections, makes characterization of the virus involved a priority. Receptor binding, the initial event in virus infection, is a major determinant of virus transmissibility that, for influenza viruses, is mediated by the hemagglutinin (HA) membrane glycoprotein. We have determined the crystal structures of the HA from the 1918 virus and two closely related HAs in complex with receptor analogs. They explain how the 1918 HA, while retaining receptor binding site amino acids characteristic of an avian precursor HA, is able to bind human receptors and how, as a consequence, the virus was able to spread in the human population.
The line below this paragraph, {{ABSTRACT_PUBMED_14764886}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 14764886 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14764886}}


==About this Structure==
==About this Structure==
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[[Category: Hemagglutinin]]
[[Category: Hemagglutinin]]
[[Category: Influenza a virus]]
[[Category: Influenza a virus]]
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