1rwq: Difference between revisions

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[[Image:1rwq.jpg|left|200px]]
{{Seed}}
[[Image:1rwq.png|left|200px]]


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{{STRUCTURE_1rwq|  PDB=1rwq  |  SCENE=  }}  
{{STRUCTURE_1rwq|  PDB=1rwq  |  SCENE=  }}  


'''Human Dipeptidyl peptidase IV in complex with 5-aminomethyl-6-(2,4-dichloro-phenyl)-2-(3,5-dimethoxy-phenyl)-pyrimidin-4-ylamine'''
===Human Dipeptidyl peptidase IV in complex with 5-aminomethyl-6-(2,4-dichloro-phenyl)-2-(3,5-dimethoxy-phenyl)-pyrimidin-4-ylamine===




==Overview==
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The influence of aromatic substitution on a newly discovered class of inhibitors of dipeptidyl peptidase IV was investigated. A 10(5)-fold increase in potency was achieved by the optimization of aromatic substituents in a parallel chemistry program. The observed SAR could be explained by an X-ray structure of the protein-ligand complex.
The line below this paragraph, {{ABSTRACT_PUBMED_15006388}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15006388 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15006388}}


==About this Structure==
==About this Structure==
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[[Category: Drug design]]
[[Category: Drug design]]
[[Category: Exopeptidase]]
[[Category: Exopeptidase]]
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