1ryf: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:1ryf.jpg|left|200px]]
{{Seed}}
[[Image:1ryf.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ryf|  PDB=1ryf  |  SCENE=  }}  
{{STRUCTURE_1ryf|  PDB=1ryf  |  SCENE=  }}  


'''Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase'''
===Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase===




==Overview==
<!--
Rac1b was recently identified in malignant colorectal tumors as an alternative splice variant of Rac1 containing a 19-amino acid insertion next to the switch II region. The structures of Rac1b in the GDP- and the GppNHp-bound forms, determined at a resolution of 1.75 A, reveal that the insertion induces an open switch I conformation and a highly mobile switch II. As a consequence, Rac1b has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. Interestingly, Rac1b is able to bind the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction. The presented study provides insights into the structural and biochemical mechanism of a self-activating GTPase.
The line below this paragraph, {{ABSTRACT_PUBMED_14625275}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 14625275 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_14625275}}


==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Fiegen, D.]]
[[Category: Fiegen, D.]]
[[Category: Gtp binding]]
[[Category: Gtp binding]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:03:50 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:17:54 2008''

Revision as of 20:17, 28 July 2008

File:1ryf.png

Template:STRUCTURE 1ryf

Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase

Template:ABSTRACT PUBMED 14625275

About this Structure

1RYF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase., Fiegen D, Haeusler LC, Blumenstein L, Herbrand U, Dvorsky R, Vetter IR, Ahmadian MR, J Biol Chem. 2004 Feb 6;279(6):4743-9. Epub 2003 Nov 18. PMID:14625275

Page seeded by OCA on Mon Jul 28 23:17:54 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1ryf&oldid=718313"