1rzb: Difference between revisions

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[[Image:1rzb.jpg|left|200px]]
{{Seed}}
[[Image:1rzb.png|left|200px]]


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{{STRUCTURE_1rzb|  PDB=1rzb  |  SCENE=  }}  
{{STRUCTURE_1rzb|  PDB=1rzb  |  SCENE=  }}  


'''X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES'''
===X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES===




==Overview==
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Metal-substituted crystals of human carbonic anhydrase II belonging to space group P2(1) with cell dimensions a = 42.7, b = 41.7, c = 73.0 A and beta = 104.6 degrees were analyzed crystallographically. The resolution limit ranged from 1.82 to 1.92 A with high completeness (86.2-90.7%). Cobalt(II)-substituted carbonic anhydrase has a tetrahedral coordination around the metal both at pH 6 and pH 7.8, similar to the native zinc enzyme. In contrast, the catalytically inactive copper(II), nickel(II) and manganese(II) derivatives showed increased coordination number around the metal ion. Whereas the copper is best described as penta-coordinated, the nickel and manganese are best described as hexa-coordinated. The results are briefly compared with spectroscopic observations and our current view on carbonic anhydrase catalysis.
The line below this paragraph, {{ABSTRACT_PUBMED_15299481}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_15299481}}


==About this Structure==
==About this Structure==
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[[Category: Liljas, A.]]
[[Category: Liljas, A.]]
[[Category: Wehnert, A.]]
[[Category: Wehnert, A.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:05:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:45:11 2008''

Revision as of 21:45, 27 July 2008

File:1rzb.png

Template:STRUCTURE 1rzb

X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES

Template:ABSTRACT PUBMED 15299481

About this Structure

1RZB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray analysis of metal-substituted human carbonic anhydrase II derivatives., Hakansson K, Wehnert A, Liljas A, Acta Crystallogr D Biol Crystallogr. 1994 Jan 1;50(Pt 1):93-100. PMID:15299481

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