1rzi: Difference between revisions

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[[Image:1rzi.~~gif~~|left|200px]]

[[Image:1rzi.png|left|200px]]

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~~'''~~Crystal structure of human anti-HIV-1 gp120-reactive antibody 47e fab~~'''~~

===Crystal structure of human anti-HIV-1 gp120-reactive antibody 47e fab===

~~==Overview==~~

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The ~~conserved surface of~~ the ~~HIV-1 gp120 envelope glycoprotein that binds~~ to the ~~HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage~~. ~~Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5~~. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)~~-gene usage. When confronted by extraordinary viral defenses~~, the ~~immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition~~.

The line below this paragraph, {{ABSTRACT_PUBMED_14981267}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 14981267 is the PubMed ID number.

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==About this Structure==

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[[Category: Tyrosine sulfation]]

[[Category: Vh-gene usage]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 08~~:06:14 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:54:25 2008''

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-[[Image:1rzi.gif|left|200px]]
+{{Seed}}
+[[Image:1rzi.png|left|200px]]
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 {{STRUCTURE_1rzi|  PDB=1rzi  |  SCENE=  }}
-'''Crystal structure of human anti-HIV-1 gp120-reactive antibody 47e fab'''
+===Crystal structure of human anti-HIV-1 gp120-reactive antibody 47e fab===
-==Overview==
+<!--
-The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.
+The line below this paragraph, {{ABSTRACT_PUBMED_14981267}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14981267 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14981267}}
 ==About this Structure==
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 [[Category: Tyrosine sulfation]]
 [[Category: Vh-gene usage]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:06:14 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:54:25 2008''