1s0u: Difference between revisions

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[[Image:1s0u.jpg|left|200px]]
{{Seed}}
[[Image:1s0u.png|left|200px]]


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{{STRUCTURE_1s0u|  PDB=1s0u  |  SCENE=  }}  
{{STRUCTURE_1s0u|  PDB=1s0u  |  SCENE=  }}  


'''eIF2gamma apo'''
===eIF2gamma apo===




==Overview==
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The x-ray structure of the gamma-subunit of the heterotrimeric translation initiation factor eIF2 has been determined to 2.4-A resolution. eIF2 is a GTPase that delivers the initiator Met-tRNA to the P site on the small ribosomal subunit during a rate-limiting initiation step in translation. The structure of eIF2gamma closely resembles that of EF1A.GTP, consisting of an N-terminal G domain followed by two beta-barrels arranged in a closed configuration with domain II packed against the G domain in the vicinity of the Switch regions. The G domain of eIF2gamma has an unusual zinc ribbon motif, not previously found in other GTPases. Structure-based site-directed mutagenesis was used to identify two adjacent features on the surface of eIF2gamma that bind the alpha-subunit and Met-tRNA(i)(Met), respectively. These structural, biochemical, and genetic results provide new insights into eIF2 ternary complex assembly.
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{{ABSTRACT_PUBMED_14688270}}


==About this Structure==
==About this Structure==
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[[Category: Translation initiation]]
[[Category: Translation initiation]]
[[Category: Trna]]
[[Category: Trna]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:09:14 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:43:34 2008''

Revision as of 15:43, 27 July 2008

File:1s0u.png

Template:STRUCTURE 1s0u

eIF2gamma apo

Template:ABSTRACT PUBMED 14688270

About this Structure

1S0U is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

X-ray structure of translation initiation factor eIF2gamma: implications for tRNA and eIF2alpha binding., Roll-Mecak A, Alone P, Cao C, Dever TE, Burley SK, J Biol Chem. 2004 Mar 12;279(11):10634-42. Epub 2003 Dec 19. PMID:14688270

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