1urn: Difference between revisions
New page: left|200px<br /> <applet load="1urn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1urn, resolution 1.920Å" /> '''U1A MUTANT/RNA COM... |
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'''U1A MUTANT/RNA COMPLEX + GLYCEROL'''<br /> | '''U1A MUTANT/RNA COMPLEX + GLYCEROL'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1URN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CL and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 1URN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1URN OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: single strand]] | [[Category: single strand]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:03:41 2008'' | ||
Revision as of 15:03, 15 February 2008
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U1A MUTANT/RNA COMPLEX + GLYCEROL
Overview
The crystal structure of the RNA-binding domain of the small nuclear, ribonucleoprotein U1A bound to a 21-nucleotide RNA hairpin has been, determined at 1.92 A resolution. The ten-nucleotide RNA loop binds to the, surface of the beta-sheet as an open structure, and the AUUGCAC sequence, of the loop interacts extensively with the conserved RNP1 and RNP2 motifs, and the C-terminal extension of the RNP domain. These interactions include, stacking of RNA bases with aromatic side chains of proteins and many, direct and water-mediated hydrogen bonds. The structure reveals the, stereochemical basis for sequence-specific RNA recognition by the RNP, domain.
About this Structure
1URN is a Single protein structure of sequence from Homo sapiens with CL and GOL as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin., Oubridge C, Ito N, Evans PR, Teo CH, Nagai K, Nature. 1994 Dec 1;372(6505):432-8. PMID:7984237
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