1s1s: Difference between revisions

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[[Image:1s1s.gif|left|200px]]
{{Seed}}
[[Image:1s1s.png|left|200px]]


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{{STRUCTURE_1s1s|  PDB=1s1s  |  SCENE=  }}  
{{STRUCTURE_1s1s|  PDB=1s1s  |  SCENE=  }}  


'''Crystal Structure of ZipA in complex with indoloquinolizin 10b'''
===Crystal Structure of ZipA in complex with indoloquinolizin 10b===




==Overview==
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The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key region of ZipA involved in FtsZ binding. The X-ray crystal structure of one of these molecules complexed with ZipA was solved. The structure revealed an unexpected binding mode, facilitated by desolvation of a loosely bound surface water.
The line below this paragraph, {{ABSTRACT_PUBMED_15006376}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_15006376}}


==About this Structure==
==About this Structure==
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[[Category: Tuckman, M.]]
[[Category: Tuckman, M.]]
[[Category: Cell cycle]]
[[Category: Cell cycle]]
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