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| {{STRUCTURE_1s21| PDB=1s21 | SCENE= }} | | {{STRUCTURE_1s21| PDB=1s21 | SCENE= }} |
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| '''Crystal Structure of AvrPphF ORF2, A Type III Effector from P. syringae'''
| | ===Crystal Structure of AvrPphF ORF2, A Type III Effector from P. syringae=== |
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| ==Overview==
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| The avrPphF locus from Pseudomonas syringae pv. phaseolicola, the causative agent of bean halo-blight disease, encodes proteins which either enhance virulence on susceptible hosts or elicit defense responses on hosts carrying the R1 resistance gene. Here we present the crystal structures of the two proteins from the avrPphF operon. The structure of AvrPphF ORF1 is strikingly reminiscent of type III chaperones from bacterial pathogens of animals, indicating structural conservation of these specialized chaperones, despite high sequence divergence. The AvrPphF ORF2 effector adopts a novel "mushroom"-like structure containing "head" and "stalk" subdomains. The head subdomain possesses limited structural homology to the catalytic domain of bacterial ADP-ribosyltransferases (ADP-RTs), though no ADP-RT activity was detected for AvrPphF ORF2 in standard assays. Nonetheless, this structural similarity identified two clusters of conserved surface-exposed residues important for both virulence mediated by AvrPphF ORF2 and recognition of this effector by bean plants expressing the R1 resistance gene. | | The line below this paragraph, {{ABSTRACT_PUBMED_15341731}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 15341731 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_15341731}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Sondek, J.]] | | [[Category: Sondek, J.]] |
| [[Category: Predominantly beta-strand]] | | [[Category: Predominantly beta-strand]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:11:58 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:23:47 2008'' |
