1s2r: Difference between revisions

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[[Image:1s2r.gif|left|200px]]
{{Seed}}
[[Image:1s2r.png|left|200px]]


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{{STRUCTURE_1s2r|  PDB=1s2r  |  SCENE=  }}  
{{STRUCTURE_1s2r|  PDB=1s2r  |  SCENE=  }}  


'''A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2'''
===A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2===




==Overview==
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The crystal structure of [d(CGCAAATTTGCG)]2 has been determined to 1.5 A resolution, representing the first high-resolution structure of this DNA fragment. The ion interactions are novel. A spermine molecule replaces a Mg2+ observed in analogous structures. Unlike lower-resolution structures, the minor groove is narrow and the major groove lacks extra Watson-Crick hydrogen bonds. In addition, a monolayer of solvent sites, including a "spine of hydration", is visible in the minor groove. The crystal of [d(CGCAAATTTGCG)]2 was grown from a solution containing spermine, magnesium, and lithium. The conformation recapitulates that of "monovalent-minus" DNA.
The line below this paragraph, {{ABSTRACT_PUBMED_15563130}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_15563130}}


==About this Structure==
==About this Structure==
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[[Category: Dodecamer]]
[[Category: Dodecamer]]
[[Category: Minor groove hydration]]
[[Category: Minor groove hydration]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:13:28 2008''
 
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