1s3q: Difference between revisions

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[[Image:1s3q.~~gif~~|left|200px]]

[[Image:1s3q.png|left|200px]]

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~~'''~~Crystal structures of a novel open pore ferritin from the hyperthermophilic Archaeon Archaeoglobus fulgidus~~'''~~

===Crystal structures of a novel open pore ferritin from the hyperthermophilic Archaeon Archaeoglobus fulgidus===

~~==Overview==~~

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~~Ferritins are known~~ as ~~important iron storage~~/detoxification proteins and are widely found in living organisms. This report details the 2.1 A resolution native and 2.7 A resolution iron bound structures of the ferritin from the hyperthermophilic Archaeon Archaeoglobus fulgidus, and represents the first structure of a ferritin from an archaeon, or a hyperthermophilic organism. ~~The A~~. ~~fulgidus ferritin (AfFtn~~) ~~monomer has a high degree of structural similarity with archetypal ferritins from E. coli and humans~~, ~~but the AfFtn quaternary structure~~ is ~~novel; 24 subunits assemble into a shell having tetrahedral (2-3) rather than~~ the ~~canonical octahedral (4~~-3-2) symmetry of archetypal ferritins. The difference in assembly opens four large (approximately 45 A) pores in the AfFtn shell. Two nonconservative amino acid substitutions may be critical for stabilizing the tetrahedral form.

The line below this paragraph, {{ABSTRACT_PUBMED_15837202}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15837202 is the PubMed ID number.

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==About this Structure==

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[[Category: Four helix bundle]]

[[Category: Iron storage]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 08~~:15:38 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:38:32 2008''

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-[[Image:1s3q.gif|left|200px]]
+{{Seed}}
+[[Image:1s3q.png|left|200px]]
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 {{STRUCTURE_1s3q|  PDB=1s3q  |  SCENE=  }}
-'''Crystal structures of a novel open pore ferritin from the hyperthermophilic Archaeon Archaeoglobus fulgidus'''
+===Crystal structures of a novel open pore ferritin from the hyperthermophilic Archaeon Archaeoglobus fulgidus===
-==Overview==
+<!--
-Ferritins are known as important iron storage/detoxification proteins and are widely found in living organisms. This report details the 2.1 A resolution native and 2.7 A resolution iron bound structures of the ferritin from the hyperthermophilic Archaeon Archaeoglobus fulgidus, and represents the first structure of a ferritin from an archaeon, or a hyperthermophilic organism. The A. fulgidus ferritin (AfFtn) monomer has a high degree of structural similarity with archetypal ferritins from E. coli and humans, but the AfFtn quaternary structure is novel; 24 subunits assemble into a shell having tetrahedral (2-3) rather than the canonical octahedral (4-3-2) symmetry of archetypal ferritins. The difference in assembly opens four large (approximately 45 A) pores in the AfFtn shell. Two nonconservative amino acid substitutions may be critical for stabilizing the tetrahedral form.
+The line below this paragraph, {{ABSTRACT_PUBMED_15837202}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15837202 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15837202}}
 ==About this Structure==
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 [[Category: Four helix bundle]]
 [[Category: Iron storage]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:15:38 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:38:32 2008''