1s5q: Difference between revisions

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[[Image:1s5q.jpg|left|200px]]
{{Seed}}
[[Image:1s5q.png|left|200px]]


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{{STRUCTURE_1s5q|  PDB=1s5q  |  SCENE=  }}  
{{STRUCTURE_1s5q|  PDB=1s5q  |  SCENE=  }}  


'''Solution Structure of Mad1 SID-mSin3A PAH2 Complex'''
===Solution Structure of Mad1 SID-mSin3A PAH2 Complex===




==Overview==
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Recruitment of the histone deacetylase (HDAC)-associated Sin3 corepressor is an obligatory step in many eukaryotic gene silencing pathways. Here we show that HBP1, a cell cycle inhibitor and regulator of differentiation, represses transcription in a HDAC/Sin3-dependent manner by targeting the mammalian Sin3A (mSin3A) PAH2 domain. HBP1 is unrelated to the Mad1 repressor for which high-resolution structures in complex with PAH2 have been described. We show that like Mad1, the HBP1 transrepression domain binds through a helical structure to the hydrophobic cleft of mSin3A PAH2. Notably, the HBP1 helix binds PAH2 in a reversed orientation relative to Mad1 and, equally unexpectedly, this is correlated with a chain reversal of the minimal Sin3 interaction motifs. These results not only provide insights into how multiple, unrelated transcription factors recruit the same coregulator, but also have implications for how sequence similarity searches are conducted.
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{{ABSTRACT_PUBMED_15235594}}


==About this Structure==
==About this Structure==
1S5Q is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S5Q OCA].  
1S5Q is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S5Q OCA].  


==Reference==
==Reference==
HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations., Swanson KA, Knoepfler PS, Huang K, Kang RS, Cowley SM, Laherty CD, Eisenman RN, Radhakrishnan I, Nat Struct Mol Biol. 2004 Aug;11(8):738-46. Epub 2004 Jul 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15235594 15235594]
HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations., Swanson KA, Knoepfler PS, Huang K, Kang RS, Cowley SM, Laherty CD, Eisenman RN, Radhakrishnan I, Nat Struct Mol Biol. 2004 Aug;11(8):738-46. Epub 2004 Jul 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15235594 15235594]
Solution structure of the interacting domains of the Mad-Sin3 complex: implications for recruitment of a chromatin-modifying complex., Brubaker K, Cowley SM, Huang K, Loo L, Yochum GS, Ayer DE, Eisenman RN, Radhakrishnan I, Cell. 2000 Nov 10;103(4):655-65. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11106735 11106735]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Protein-peptide complex]]
[[Category: Protein-peptide complex]]
[[Category: Repressor-corepressor complex]]
[[Category: Repressor-corepressor complex]]
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