1v41: Difference between revisions
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New page: left|200px<br /> <applet load="1v41" size="450" color="white" frame="true" align="right" spinBox="true" caption="1v41, resolution 2.85Å" /> '''Crystal structure o... |
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[[Image:1v41.gif|left|200px]]<br /> | [[Image:1v41.gif|left|200px]]<br /><applet load="1v41" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1v41" size=" | |||
caption="1v41, resolution 2.85Å" /> | caption="1v41, resolution 2.85Å" /> | ||
'''Crystal structure of human PNP complexed with 8-Azaguanine'''<br /> | '''Crystal structure of human PNP complexed with 8-Azaguanine'''<br /> | ||
==Overview== | ==Overview== | ||
Purine nucleoside phosphorylase (PNP) is a key enzyme in the | Purine nucleoside phosphorylase (PNP) is a key enzyme in the purine-salvage pathway, which allows cells to utilize preformed bases and nucleosides in order to synthesize nucleotides. PNP is specific for purine nucleosides in the beta-configuration and exhibits a strong preference for purines containing a 6-keto group and ribosyl-containing nucleosides relative to the corresponding analogues. PNP was crystallized in complex with ligands and data collection was performed using synchrotron radiation. This work reports the structure of human PNP in complex with guanosine (at 2.80 A resolution), 3'-deoxyguanosine (at 2.86 A resolution) and 8-azaguanine (at 2.85 A resolution). These structures were compared with the PNP-guanine, PNP-inosine and PNP-immucillin-H complexes solved previously. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1V41 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and AZG as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] Full crystallographic information is available from [http:// | 1V41 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=AZG:'>AZG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V41 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Purine-nucleoside phosphorylase]] | [[Category: Purine-nucleoside phosphorylase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Basso, L | [[Category: Basso, L A.]] | ||
[[Category: Canduri, F.]] | [[Category: Canduri, F.]] | ||
[[Category: Jr., W | [[Category: Jr., W F.De Azevedo.]] | ||
[[Category: Mendes, M | [[Category: Mendes, M A.]] | ||
[[Category: Palma, M | [[Category: Palma, M S.]] | ||
[[Category: Santos, D | [[Category: Santos, D M.Dos.]] | ||
[[Category: Santos, D | [[Category: Santos, D S.]] | ||
[[Category: Silva, R | [[Category: Silva, R G.]] | ||
[[Category: AZG]] | [[Category: AZG]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
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[[Category: sybcgritron]] | [[Category: sybcgritron]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:31:17 2008'' | ||
