5vbu: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vbu OCA], [https://pdbe.org/5vbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vbu RCSB], [https://www.ebi.ac.uk/pdbsum/5vbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vbu ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vbu OCA], [https://pdbe.org/5vbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vbu RCSB], [https://www.ebi.ac.uk/pdbsum/5vbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vbu ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/CP21A_HUMAN CP21A_HUMAN] Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, salt wasting form;Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, simple virilizing form. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/ | [https://www.uniprot.org/uniprot/CP21A_HUMAN CP21A_HUMAN] A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids (PubMed:10602386, PubMed:16984992, PubMed:22014889, PubMed:25855791, PubMed:27721825). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:25855791).<ref>PMID:10602386</ref> <ref>PMID:16984992</ref> <ref>PMID:22014889</ref> <ref>PMID:25855791</ref> <ref>PMID:27721825</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
