1sbs: Difference between revisions

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[[Image:1sbs.gif|left|200px]]
{{Seed}}
[[Image:1sbs.png|left|200px]]


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{{STRUCTURE_1sbs|  PDB=1sbs  |  SCENE=  }}  
{{STRUCTURE_1sbs|  PDB=1sbs  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF AN ANTI-HCG FAB'''
===CRYSTAL STRUCTURE OF AN ANTI-HCG FAB===




==Overview==
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3A2 is an antibody raised against human chorionic gonadotropin and recognizes a linear epitope on the C-terminal peptide of the human chorionic gonadotropin beta-subunit. Its three-dimensional structure has been determined to 2-A resolution using molecular replacement and refined to a conventional R-factor of 18.2%. The protein exhibits the typical immunoglobulin fold, and the model contains 944 ordered water molecules and one sulfate ion. A comparison of the complementarity-determining regions of the Fab3A2 with those from the Protein Data Bank following the canonical structure method reveals a canonical main chain conformation. This antibody belongs to the canonical structure class (combination of canonical conformations of the complementarity determining loops) that shows a preference for haptens and not for peptides. However, the shape of the surface of the antigen binding loops resembles that of an anti-peptide antibody.
The line below this paragraph, {{ABSTRACT_PUBMED_9712877}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9712877 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9712877}}


==About this Structure==
==About this Structure==
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[[Category: Monoclonal antibody]]
[[Category: Monoclonal antibody]]
[[Category: Reproduction]]
[[Category: Reproduction]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:31:23 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:47:40 2008''

Revision as of 21:47, 27 July 2008

File:1sbs.png

Template:STRUCTURE 1sbs

CRYSTAL STRUCTURE OF AN ANTI-HCG FAB

Template:ABSTRACT PUBMED 9712877

About this Structure

1SBS is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of an Fab fragment against a C-terminal peptide of hCG at 2.0 A resolution., Fotinou C, Beauchamp J, Emsley P, deHaan A, Schielen WJ, Bos E, Isaacs NW, J Biol Chem. 1998 Aug 28;273(35):22515-8. PMID:9712877

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