1vcb: Difference between revisions

Line 1:

[[Image:1vcb.gif|left|200px]]<br />

[[Image:1vcb.gif|left|200px]]<br /><applet load="1vcb" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1vcb" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1vcb, resolution 2.7Å" />

'''THE VHL-ELONGINC-ELONGINB STRUCTURE'''<br />

==Overview==

Mutation of the VHL tumor suppressor is associated with the inherited von, Hippel-Lindau (VHL) cancer syndrome and the majority of kidney cancers., VHL binds the ElonginC-ElonginB complex and regulates levels of, hypoxia-inducible proteins. The structure of the ternary complex at 2.7, angstrom resolution shows two interfaces, one between VHL and ElonginC and, another between ElonginC and ElonginB. Tumorigenic mutations frequently, occur in a 35-residue domain of VHL responsible for ElonginC binding. A, mutational patch on a separate domain of VHL indicates a second, macromolecular binding site. The structure extends the similarities to the, SCF (Skp1-Cul1-F-box protein) complex that targets proteins for, degradation, supporting the hypothesis that VHL may function in an, analogous pathway.

Mutation of the VHL tumor suppressor is associated with the inherited von Hippel-Lindau (VHL) cancer syndrome and the majority of kidney cancers. VHL binds the ElonginC-ElonginB complex and regulates levels of hypoxia-inducible proteins. The structure of the ternary complex at 2.7 angstrom resolution shows two interfaces, one between VHL and ElonginC and another between ElonginC and ElonginB. Tumorigenic mutations frequently occur in a 35-residue domain of VHL responsible for ElonginC binding. A mutational patch on a separate domain of VHL indicates a second macromolecular binding site. The structure extends the similarities to the SCF (Skp1-Cul1-F-box protein) complex that targets proteins for degradation, supporting the hypothesis that VHL may function in an analogous pathway.

==Disease==

Line 11:

Line 10:

==About this Structure==

1VCB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1VCB OCA].

1VCB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VCB OCA].

==Reference==

Line 17:

Line 16:

[[Category: Homo sapiens]]

[[Category: Protein complex]]

[[Category: Kaelin, W.G.]]

[[Category: Kaelin, W G.]]

[[Category: Pavletich, N.P.]]

[[Category: Pavletich, N P.]]

[[Category: Stebbins, C.E.]]

[[Category: Stebbins, C E.]]

[[Category: beta sandwich]]

[[Category: cancer]]

Line 27:

Line 26:

[[Category: ubiquitin]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 19~~:43:~~09 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:33:48 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1vcb.gif|left|200px]]<br />
+[[Image:1vcb.gif|left|200px]]<br /><applet load="1vcb" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1vcb" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1vcb, resolution 2.7&Aring;" />
 '''THE VHL-ELONGINC-ELONGINB STRUCTURE'''<br />
 ==Overview==
-Mutation of the VHL tumor suppressor is associated with the inherited von, Hippel-Lindau (VHL) cancer syndrome and the majority of kidney cancers., VHL binds the ElonginC-ElonginB complex and regulates levels of, hypoxia-inducible proteins. The structure of the ternary complex at 2.7, angstrom resolution shows two interfaces, one between VHL and ElonginC and, another between ElonginC and ElonginB. Tumorigenic mutations frequently, occur in a 35-residue domain of VHL responsible for ElonginC binding. A, mutational patch on a separate domain of VHL indicates a second, macromolecular binding site. The structure extends the similarities to the, SCF (Skp1-Cul1-F-box protein) complex that targets proteins for, degradation, supporting the hypothesis that VHL may function in an, analogous pathway.
+Mutation of the VHL tumor suppressor is associated with the inherited von Hippel-Lindau (VHL) cancer syndrome and the majority of kidney cancers. VHL binds the ElonginC-ElonginB complex and regulates levels of hypoxia-inducible proteins. The structure of the ternary complex at 2.7 angstrom resolution shows two interfaces, one between VHL and ElonginC and another between ElonginC and ElonginB. Tumorigenic mutations frequently occur in a 35-residue domain of VHL responsible for ElonginC binding. A mutational patch on a separate domain of VHL indicates a second macromolecular binding site. The structure extends the similarities to the SCF (Skp1-Cul1-F-box protein) complex that targets proteins for degradation, supporting the hypothesis that VHL may function in an analogous pathway.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-VCB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1VCB OCA].
+VCB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VCB OCA].
 ==Reference==
@@ Line 17: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Protein complex]]
-[[Category: Kaelin, W.G.]]
+[[Category: Kaelin, W G.]]
-[[Category: Pavletich, N.P.]]
+[[Category: Pavletich, N P.]]
-[[Category: Stebbins, C.E.]]
+[[Category: Stebbins, C E.]]
 [[Category: beta sandwich]]
 [[Category: cancer]]
@@ Line 27: / Line 26: @@
 [[Category: ubiquitin]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:43:09 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:33:48 2008''