8cnl: Difference between revisions
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==Lymphocytic choriomeningitis virus 3'-5' exonuclease domain of nucleoprotein== | |||
<StructureSection load='8cnl' size='340' side='right'caption='[[8cnl]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8cnl]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Arenavirus Arenavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CNL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cnl OCA], [https://pdbe.org/8cnl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cnl RCSB], [https://www.ebi.ac.uk/pdbsum/8cnl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cnl ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Ferron | == Function == | ||
[[Category: Papageorgiou | [https://www.uniprot.org/uniprot/NCAP_LYCVA NCAP_LYCVA] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation.<ref>PMID:12610166</ref> <ref>PMID:17804508</ref> <ref>PMID:22532683</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Arenavirus]] | |||
[[Category: Large Structures]] | |||
[[Category: Ferron F]] | |||
[[Category: Papageorgiou N]] | |||
[[Category: Spiliopoulou M]] | |||
Latest revision as of 06:02, 11 September 2024
Lymphocytic choriomeningitis virus 3'-5' exonuclease domain of nucleoprotein
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