8jiz: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 8jiz is ON HOLD until Paper Publication~~

==Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab5F6 in two fab bind conformation==

~~Authors: Wang, H., Zhu, S.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[8jiz]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JIZ OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8JIZ FirstGlance].

~~Description:~~ Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab5F6 in two fab bind conformation

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8Å</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

[[Category: ~~Zhu, S~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8jiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jiz OCA], [https://pdbe.org/8jiz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jiz RCSB], [https://www.ebi.ac.uk/pdbsum/8jiz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jiz ProSAT]</td></tr>

[[Category: Wang, H]]

</table>

== Disease ==

[https://www.uniprot.org/uniprot/NMDE1_HUMAN NMDE1_HUMAN] Landau-Kleffner syndrome;Early-onset epileptic encephalopathy and intellectual disability due to GRIN2A mutation;Continuous spikes and waves during sleep;Rolandic epilepsy;Rolandic epilepsy - speech dyspraxia. The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving GRIN2A has been found in a family with epilepsy and neurodevelopmental defects. Translocation t(16;17)(p13.2;q11.2). GRIN2A somatic mutations have been frequently found in cutaneous malignant melanoma, suggesting that the glutamate signaling pathway may play a role in the pathogenesis of melanoma.<ref>PMID:21499247</ref> <ref>PMID:24455489</ref>

== Function ==

[https://www.uniprot.org/uniprot/NMDE1_HUMAN NMDE1_HUMAN] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Wang H]]

[[Category: Zhu S]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8jiz is ON HOLD  until Paper Publication
+==Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab5F6 in two fab bind conformation==
+<StructureSection load='8jiz' size='340' side='right'caption='[[8jiz]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
-Authors: Wang, H., Zhu, S.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8jiz]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JIZ FirstGlance]. <br>
-Description: Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab5F6 in two fab bind conformation
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-[[Category: Zhu, S]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jiz OCA], [https://pdbe.org/8jiz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jiz RCSB], [https://www.ebi.ac.uk/pdbsum/8jiz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jiz ProSAT]</span></td></tr>
-[[Category: Wang, H]]
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/NMDE1_HUMAN NMDE1_HUMAN] Landau-Kleffner syndrome;Early-onset epileptic encephalopathy and intellectual disability due to GRIN2A mutation;Continuous spikes and waves during sleep;Rolandic epilepsy;Rolandic epilepsy - speech dyspraxia. The disease is caused by mutations affecting the gene represented in this entry.  A chromosomal aberration involving GRIN2A has been found in a family with epilepsy and neurodevelopmental defects. Translocation t(16;17)(p13.2;q11.2).  GRIN2A somatic mutations have been frequently found in cutaneous malignant melanoma, suggesting that the glutamate signaling pathway may play a role in the pathogenesis of melanoma.<ref>PMID:21499247</ref> <ref>PMID:24455489</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/NMDE1_HUMAN NMDE1_HUMAN] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Wang H]]
+[[Category: Zhu S]]