8p2p: Difference between revisions

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'''Unreleased structure'''


The entry 8p2p is ON HOLD  until Paper Publication
==Polymeric form of the BTB domain of human ZBTB18==
 
<StructureSection load='8p2p' size='340' side='right'caption='[[8p2p]], [[Resolution|resolution]] 4.15&Aring;' scene=''>
Authors: Coste, F., Mance, L., Pukalo, Z., Suskiewicz, M.J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8p2p]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P2P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P2P FirstGlance]. <br>
Description: Polymeric form of the BTB domain of human ZBTB18
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.15&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p2p OCA], [https://pdbe.org/8p2p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p2p RCSB], [https://www.ebi.ac.uk/pdbsum/8p2p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p2p ProSAT]</span></td></tr>
[[Category: Suskiewicz, M.J]]
</table>
[[Category: Coste, F]]
== Disease ==
[[Category: Mance, L]]
[https://www.uniprot.org/uniprot/ZBT18_HUMAN ZBT18_HUMAN] Distal deletion 1q. The disease is caused by variants affecting the gene represented in this entry.
[[Category: Pukalo, Z]]
== Function ==
[https://www.uniprot.org/uniprot/ZBT18_HUMAN ZBT18_HUMAN] Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus.<ref>PMID:9756912</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Coste F]]
[[Category: Mance L]]
[[Category: Pukalo Z]]
[[Category: Suskiewicz MJ]]
Retrieved from "https://proteopedia.org/8p2p"