1sdb: Difference between revisions

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[[Image:1sdb.jpg|left|200px]]
{{Seed}}
[[Image:1sdb.png|left|200px]]


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{{STRUCTURE_1sdb|  PDB=1sdb  |  SCENE=  }}  
{{STRUCTURE_1sdb|  PDB=1sdb  |  SCENE=  }}  


'''PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN'''
===PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN===




==Overview==
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Insulin has a concentration of 10(-8)-10(-11) M in the blood which ensures that it circulates and exerts its physiological functions in vivo as a monomer. The crystal structure of monomeric porcine desB1-B2 despentapeptide (B26-B30) insulin (DesB1-2 DPI) with M(r) = 4934 Da has been determined at 1.65 A resolution using the molecular replacement method. A structural comparison between DesB1-2 DPI and 2Zn insulin reveals that the conformation of DesB1-2 DPI is more similar to molecule I than molecule II of 2Zn insulin. The remarkable conformational difference between B25-Phe in DesB1-2 DPI and B25-Phe in despentapeptide (B26-B30) insulin (DPI) indicates that the residue B25-Phe possesses great flexibility and mobility.
The line below this paragraph, {{ABSTRACT_PUBMED_15299880}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15299880 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15299880}}


==About this Structure==
==About this Structure==
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[[Category: Liang, D C.]]
[[Category: Liang, D C.]]
[[Category: Hormone]]
[[Category: Hormone]]
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