8s0d: Difference between revisions

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'''Unreleased structure'''


The entry 8s0d is ON HOLD  until Paper Publication
==H. sapiens MCM bound to double stranded DNA and ORC1-6==
 
<StructureSection load='8s0d' size='340' side='right'caption='[[8s0d]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
Authors: Greiwe, J.F., Weissmann, F., Diffley, J.F.X., Costa, A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8s0d]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8S0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8S0D FirstGlance]. <br>
Description: H. sapiens MCM bound to double stranded DNA and ORC1-6
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Greiwe, J.F]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8s0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8s0d OCA], [https://pdbe.org/8s0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8s0d RCSB], [https://www.ebi.ac.uk/pdbsum/8s0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8s0d ProSAT]</span></td></tr>
[[Category: Weissmann, F]]
</table>
[[Category: Costa, A]]
== Disease ==
[[Category: Diffley, J.F.X]]
[https://www.uniprot.org/uniprot/ORC1_HUMAN ORC1_HUMAN] Ear-patella-short stature syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/ORC1_HUMAN ORC1_HUMAN] Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Costa A]]
[[Category: Diffley JFX]]
[[Category: Greiwe JF]]
[[Category: Weissmann F]]
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