8stc: Difference between revisions

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'''Unreleased structure'''


The entry 8stc is ON HOLD  until Paper Publication
==S127A variant of LarB, a carboxylase/hydrolase involved in synthesis of the cofactor for lactate racemase, in complex with Zinc and soaked with bicarbonate.==
 
<StructureSection load='8stc' size='340' side='right'caption='[[8stc]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
Authors: Chatterjee, S., Rankin, J.A., Hu, J., Hausinger, R.P.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8stc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactiplantibacillus_plantarum_WCFS1 Lactiplantibacillus plantarum WCFS1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8STC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8STC FirstGlance]. <br>
Description: S127A variant of LarB, a carboxylase/hydrolase involved in synthesis of the cofactor for lactate racemase, in complex with Zinc and soaked with bicarbonate.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Rankin, J.A]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8stc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8stc OCA], [https://pdbe.org/8stc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8stc RCSB], [https://www.ebi.ac.uk/pdbsum/8stc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8stc ProSAT]</span></td></tr>
[[Category: Hu, J]]
</table>
[[Category: Hausinger, R.P]]
== Function ==
[[Category: Chatterjee, S]]
[https://www.uniprot.org/uniprot/LARB_LACPL LARB_LACPL] Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Carboxylates the pyridinium ring of nicotinic acid adenine dinucleotide (NaAD) and cleaves the phosphoanhydride bond to release AMP and generate pyridinium-3,5-biscarboxylic acid mononucleotide (P2CMN) (PubMed:27114550). LarB can hydrolyze NaAD directly or it first forms an adduct with NaAD that releases AMP and reacts with bicarbonate/CO2 to generate P2CMN (PubMed:27114550). Is required for the activation of the lactate racemase LarA (PubMed:24710389). May also be involved in the activation of other nickel-pincer cofactor-dependent enzymes (PubMed:27114550).<ref>PMID:24710389</ref> <ref>PMID:27114550</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Lactiplantibacillus plantarum WCFS1]]
[[Category: Large Structures]]
[[Category: Chatterjee S]]
[[Category: Hausinger RP]]
[[Category: Hu J]]
[[Category: Rankin JA]]
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