1sdw: Difference between revisions

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[[Image:1sdw.gif|left|200px]]
{{Seed}}
[[Image:1sdw.png|left|200px]]


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{{STRUCTURE_1sdw|  PDB=1sdw  |  SCENE=  }}  
{{STRUCTURE_1sdw|  PDB=1sdw  |  SCENE=  }}  


'''Reduced (Cu+) peptidylglycine alpha-hydroxylating monooxygenase with bound peptide and dioxygen'''
===Reduced (Cu+) peptidylglycine alpha-hydroxylating monooxygenase with bound peptide and dioxygen===




==Overview==
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Copper active sites play a major role in enzymatic activation of dioxygen. We trapped the copper-dioxygen complex in the enzyme peptidylglycine-alphahydroxylating monooxygenase (PHM) by freezing protein crystals that had been soaked with a slow substrate and ascorbate in the presence of oxygen. The x-ray crystal structure of this precatalytic complex, determined to 1.85-angstrom resolution, shows that oxygen binds to one of the coppers in the enzyme with an end-on geometry. Given this structure, it is likely that dioxygen is directly involved in the electron transfer and hydrogen abstraction steps of the PHM reaction. These insights may apply to other copper oxygen-activating enzymes, such as dopamine beta-monooxygenase, and to the design of biomimetic complexes.
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(as it appears on PubMed at http://www.pubmed.gov), where 15131304 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15131304}}


==About this Structure==
==About this Structure==
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[[Category: Prigge, S T.]]
[[Category: Prigge, S T.]]
[[Category: Beta jelly-roll]]
[[Category: Beta jelly-roll]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:35:24 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:12:21 2008''

Revision as of 16:12, 27 July 2008

File:1sdw.png

Template:STRUCTURE 1sdw

Reduced (Cu+) peptidylglycine alpha-hydroxylating monooxygenase with bound peptide and dioxygen

Template:ABSTRACT PUBMED 15131304

About this Structure

1SDW is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Dioxygen binds end-on to mononuclear copper in a precatalytic enzyme complex., Prigge ST, Eipper BA, Mains RE, Amzel LM, Science. 2004 May 7;304(5672):864-7. PMID:15131304

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