8w8l: Difference between revisions
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==Crystal structure of bacterial prolyl-tRNA synthetase in complex with inhibitor PAA-38== | |||
<StructureSection load='8w8l' size='340' side='right'caption='[[8w8l]], [[Resolution|resolution]] 1.82Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8w8l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_148 Pseudomonas aeruginosa 148]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8W8L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8W8L FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.824Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8w8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8w8l OCA], [https://pdbe.org/8w8l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8w8l RCSB], [https://www.ebi.ac.uk/pdbsum/8w8l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8w8l ProSAT]</span></td></tr> | ||
[[Category: Luo | </table> | ||
[[Category: Zhou | == Function == | ||
[https://www.uniprot.org/uniprot/SYP_PSEAE SYP_PSEAE] Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Pseudomonas aeruginosa 148]] | |||
[[Category: Luo Z]] | |||
[[Category: Zhou H]] | |||
Latest revision as of 05:39, 4 September 2024
Crystal structure of bacterial prolyl-tRNA synthetase in complex with inhibitor PAA-38
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