8wpn: Difference between revisions
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==Cryo-EM structure of the human TRPC4 in lipid nanodiscs== | |||
<StructureSection load='8wpn' size='340' side='right'caption='[[8wpn]], [[Resolution|resolution]] 2.82Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8wpn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WPN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.82Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LPP:2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL+HEXADECANOATE'>LPP</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: Jeong | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wpn OCA], [https://pdbe.org/8wpn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wpn RCSB], [https://www.ebi.ac.uk/pdbsum/8wpn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wpn ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[https://www.uniprot.org/uniprot/TRPC4_HUMAN TRPC4_HUMAN] Forms a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.<ref>PMID:16144838</ref> <ref>PMID:19996314</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Jeong H]] | |||
[[Category: Lee HH]] | |||
[[Category: Won J]] | |||
Latest revision as of 04:14, 17 October 2024
Cryo-EM structure of the human TRPC4 in lipid nanodiscs
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