8y7m: Difference between revisions

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'''Unreleased structure'''


The entry 8y7m is ON HOLD  until Paper Publication
==FluPol-NS2 complex (local refinement)==
 
<StructureSection load='8y7m' size='340' side='right'caption='[[8y7m]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
Authors: Peng, Q., Sun, J.Q.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8y7m]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Hong_Kong/1/1968(H3N2)) Influenza A virus (A/Hong Kong/1/1968(H3N2))] and [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/nt/60/1968(H3N2)) Influenza A virus (A/nt/60/1968(H3N2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Y7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Y7M FirstGlance]. <br>
Description: FluPol-NS2 complex (local refinement)
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8y7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8y7m OCA], [https://pdbe.org/8y7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8y7m RCSB], [https://www.ebi.ac.uk/pdbsum/8y7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8y7m ProSAT]</span></td></tr>
[[Category: Peng, Q]]
</table>
[[Category: Sun, J.Q]]
== Function ==
[https://www.uniprot.org/uniprot/PA_I68A6 PA_I68A6] Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.[HAMAP-Rule:MF_04063]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Peng Q]]
[[Category: Sun JQ]]
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