8z5a: Difference between revisions
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==Crystal Structure of Nur77 LBD in complex with NLM1== | |||
<StructureSection load='8z5a' size='340' side='right'caption='[[8z5a]], [[Resolution|resolution]] 2.18Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8z5a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Z5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Z5A FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.179Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1D72:5-[[4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]-~{N}-(3-morpholin-4-ylpropyl)-1~{H}-indole-2-carboxamide'>A1D72</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8z5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8z5a OCA], [https://pdbe.org/8z5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8z5a RCSB], [https://www.ebi.ac.uk/pdbsum/8z5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8z5a ProSAT]</span></td></tr> | ||
[[Category: Hong | </table> | ||
[[Category: | == Function == | ||
[https://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen XQ]] | |||
[[Category: Hong WB]] | |||
[[Category: Lin TW]] | |||
Latest revision as of 05:16, 23 April 2025
Crystal Structure of Nur77 LBD in complex with NLM1
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