8z93: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Cryo-EM structure of amyloid fibril formed by human RIPK1 RHIM protein== | |||
<StructureSection load='8z93' size='340' side='right'caption='[[8z93]], [[Resolution|resolution]] 4.65Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8z93]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Z93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Z93 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.65Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8z93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8z93 OCA], [https://pdbe.org/8z93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8z93 RCSB], [https://www.ebi.ac.uk/pdbsum/8z93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8z93 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Liu | == Function == | ||
[[Category: Zhao | [https://www.uniprot.org/uniprot/RIPK1_HUMAN RIPK1_HUMAN] Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.<ref>PMID:11101870</ref> <ref>PMID:19524513</ref> <ref>PMID:19524512</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Liu C]] | |||
[[Category: Ma Y]] | |||
[[Category: Zhao K]] | |||
Latest revision as of 10:24, 30 April 2025
Cryo-EM structure of amyloid fibril formed by human RIPK1 RHIM protein
| ||||||||||||
