1sfc: Difference between revisions

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[[Image:1sfc.gif|left|200px]]
{{Seed}}
[[Image:1sfc.png|left|200px]]


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{{STRUCTURE_1sfc|  PDB=1sfc  |  SCENE=  }}  
{{STRUCTURE_1sfc|  PDB=1sfc  |  SCENE=  }}  


'''NEURONAL SYNAPTIC FUSION COMPLEX'''
===NEURONAL SYNAPTIC FUSION COMPLEX===




==Overview==
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The evolutionarily conserved SNARE proteins and their complexes are involved in the fusion of vesicles with their target membranes; however, the overall organization and structural details of these complexes are unknown. Here we report the X-ray crystal structure at 2.4 A resolution of a core synaptic fusion complex containing syntaxin-1 A, synaptobrevin-II and SNAP-25B. The structure reveals a highly twisted and parallel four-helix bundle that differs from the bundles described for the haemagglutinin and HIV/SIV gp41 membrane-fusion proteins. Conserved leucine-zipper-like layers are found at the centre of the synaptic fusion complex. Embedded within these leucine-zipper layers is an ionic layer consisting of an arginine and three glutamine residues contributed from each of the four alpha-helices. These residues are highly conserved across the entire SNARE family. The regions flanking the leucine-zipper-like layers contain a hydrophobic core similar to that of more general four-helix-bundle proteins. The surface of the synaptic fusion complex is highly grooved and possesses distinct hydrophilic, hydrophobic and charged regions. These characteristics may be important for membrane fusion and for the binding of regulatory factors affecting neurotransmission.
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{{ABSTRACT_PUBMED_9759724}}


==About this Structure==
==About this Structure==
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[[Category: Sutton, R B.]]
[[Category: Sutton, R B.]]
[[Category: Membrane fusion protein complex]]
[[Category: Membrane fusion protein complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:37:53 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:36:35 2008''

Revision as of 12:36, 29 July 2008

File:1sfc.png

Template:STRUCTURE 1sfc

NEURONAL SYNAPTIC FUSION COMPLEX

Template:ABSTRACT PUBMED 9759724

About this Structure

1SFC is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution., Sutton RB, Fasshauer D, Jahn R, Brunger AT, Nature. 1998 Sep 24;395(6700):347-53. PMID:9759724

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