1vsc: Difference between revisions

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[[Image:1vsc.gif|left|200px]]<br />

[[Image:1vsc.gif|left|200px]]<br /><applet load="1vsc" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1vsc" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1vsc, resolution 1.9Å" />

'''VCAM-1'''<br />

==Overview==

Vascular cell adhesion molecule 1 (VCAM-1) represents a structurally and, functionally distinct class of immunoglobulin superfamily molecules that, bind leukocyte integrins and are involved in inflammatory and immune, functions. X-ray crystallography defines the three-dimensional structure, of the N-terminal two-domain fragment that participates in ligand binding., Residues in domain 1 important for ligand binding reside in the C-D loop, which projects markedly from one face of the molecule near the contact, between domains 1 and 2. A cyclic peptide that mimics this loop inhibits, binding of alpha 4 beta 1 integrin-bearing cells to VCAM-1. These data, demonstrate how crystallographic structural information can be used to, design a small molecule inhibitor of biological function.

Vascular cell adhesion molecule 1 (VCAM-1) represents a structurally and functionally distinct class of immunoglobulin superfamily molecules that bind leukocyte integrins and are involved in inflammatory and immune functions. X-ray crystallography defines the three-dimensional structure of the N-terminal two-domain fragment that participates in ligand binding. Residues in domain 1 important for ligand binding reside in the C-D loop, which projects markedly from one face of the molecule near the contact between domains 1 and 2. A cyclic peptide that mimics this loop inhibits binding of alpha 4 beta 1 integrin-bearing cells to VCAM-1. These data demonstrate how crystallographic structural information can be used to design a small molecule inhibitor of biological function.

==Disease==

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==About this Structure==

1VSC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1VSC OCA].

1VSC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VSC OCA].

==Reference==

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[[Category: immunoglobulin fold]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 19~~:44:~~49 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:38:12 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1vsc.gif|left|200px]]<br />
+[[Image:1vsc.gif|left|200px]]<br /><applet load="1vsc" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1vsc" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1vsc, resolution 1.9&Aring;" />
 '''VCAM-1'''<br />
 ==Overview==
-Vascular cell adhesion molecule 1 (VCAM-1) represents a structurally and, functionally distinct class of immunoglobulin superfamily molecules that, bind leukocyte integrins and are involved in inflammatory and immune, functions. X-ray crystallography defines the three-dimensional structure, of the N-terminal two-domain fragment that participates in ligand binding., Residues in domain 1 important for ligand binding reside in the C-D loop, which projects markedly from one face of the molecule near the contact, between domains 1 and 2. A cyclic peptide that mimics this loop inhibits, binding of alpha 4 beta 1 integrin-bearing cells to VCAM-1. These data, demonstrate how crystallographic structural information can be used to, design a small molecule inhibitor of biological function.
+Vascular cell adhesion molecule 1 (VCAM-1) represents a structurally and functionally distinct class of immunoglobulin superfamily molecules that bind leukocyte integrins and are involved in inflammatory and immune functions. X-ray crystallography defines the three-dimensional structure of the N-terminal two-domain fragment that participates in ligand binding. Residues in domain 1 important for ligand binding reside in the C-D loop, which projects markedly from one face of the molecule near the contact between domains 1 and 2. A cyclic peptide that mimics this loop inhibits binding of alpha 4 beta 1 integrin-bearing cells to VCAM-1. These data demonstrate how crystallographic structural information can be used to design a small molecule inhibitor of biological function.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-VSC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1VSC OCA].
+VSC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VSC OCA].
 ==Reference==
@@ Line 24: / Line 23: @@
 [[Category: immunoglobulin fold]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:44:49 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:38:12 2008''